Ikaros Isoforms in Human Pituitary Tumors

Nerve growth factor, D2 receptor isoforms, and pituitary tumors.

Dopamine (DA), by interacting with D2 receptors (D2R), exerts two major effects in the anterior pituitary: It inhibits prolactin (PRL) secretion and controls lactotrope cell proliferation, playing a role during pituitary development and tumorigenesis. In 1982, it was first reported that the spontaneous development of prolactinomas in old female rats was associated with the loss of hypothalamic ...

Pituitary tumors.

The Role of Ikaros in Human Erythroid Differentiation. Short Title : Ikaros and human erythroid differentiation

Incidence of pituitary tumors in the human population of Croatia.

Pituitary tumors are rare tumors (less then 10%) of the central nervous system (CNS), which malignicity depends on their localization, meanwhile, their biological nature is benign. The diameter they have is mostly less then 10 mm (microadenomas), but sometimes could be 10 mm (macroadenomas) to 5 cm and more and then are usually nonfunctional (about 20% of all pituitary tumors). Clinical presenc...

DNA ploidy and cell phase in human pituitary tumors.

The flow-cytofluorometric technique for nuclear DNA analysis was used in the study of 47 consecutive cases with pituitary tumors. The material consisted of 18 tumors secreting growth hormone (GH), 10 secreting GH and prolactin (PRL), 10 prolactinomas, 2 secreting thyroid-stimulating hormone (TSH), 2 secreting ACTH, and 5 were nonsecreting. An aneuploid DNA pattern occurred in 23 of 47 (49%) cas...